ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 122/762 423/7206 2.58063058465e-27 ko04724 Glutamatergic synapse 53/762 152/7206 4.56922651087e-16 ko05033 Nicotine addiction 30/762 56/7206 1.41796579458e-15 ko04713 Circadian entrainment 46/762 136/7206 1.53622177305e-13 ko04020 Calcium signaling pathway 68/762 265/7206 1.12564752979e-12 ko04974 Protein digestion and absorption 34/762 96/7206 5.81107496703e-11 ko04911 Insulin secretion 37/762 117/7206 3.53900977471e-10 ko04727 GABAergic synapse 35/762 110/7206 8.87346626249e-10 ko05032 Morphine addiction 35/762 110/7206 8.87346626249e-10 ko04725 Cholinergic synapse 44/762 160/7206 1.18472704309e-09 ko04721 Synaptic vesicle cycle 28/762 80/7206 3.99321266195e-09 ko04024 cAMP signaling pathway 60/762 279/7206 4.58389378052e-08 ko04022 cGMP-PKG signaling pathway 50/762 216/7206 5.66372328527e-08 ko04728 Dopaminergic synapse 44/762 185/7206 1.56116333441e-07 ko04512 ECM-receptor interaction 25/762 79/7206 2.60941890326e-07 ko04970 Salivary secretion 28/762 95/7206 2.688500431e-07 ko04723 Retrograde endocannabinoid signaling 41/762 175/7206 6.23730418142e-07 ko04742 Taste transduction 20/762 61/7206 2.21326025992e-06 ko04921 Oxytocin signaling pathway 45/762 209/7206 2.99571564364e-06 ko03040 Spliceosome 1/762 145/7206 3.27361901086e-06 ko04726 Serotonergic synapse 33/762 137/7206 4.00779128488e-06 ko04120 Ubiquitin mediated proteolysis 1/762 138/7206 4.59808221553e-06 ko04971 Gastric acid secretion 26/762 98/7206 6.32645619483e-06 ko05203 Viral carcinogenesis 9/762 277/7206 8.61288093232e-06 ko04514 Cell adhesion molecules (CAMs) 31/762 130/7206 9.75684756655e-06 ko05322 Systemic lupus erythematosus 2/762 151/7206 1.21450940962e-05 ko03013 RNA transport 3/762 166/7206 1.79154070959e-05 ko05168 Herpes simplex infection 4/762 182/7206 2.38099540436e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 20/762 74/7206 5.50888682442e-05 ko04261 Adrenergic signaling in cardiomyocytes 40/762 205/7206 0.000113532824736 ko04730 Long-term depression 20/762 78/7206 0.000123008095154 ko00643 Styrene degradation 4/762 4/7206 0.000124159408357 ko05030 Cocaine addiction 19/762 73/7206 0.000145859996437 ko04270 Vascular smooth muscle contraction 32/762 154/7206 0.000157726309022 ko05031 Amphetamine addiction 21/762 91/7206 0.000445630429318 ko04924 Renin secretion 20/762 86/7206 0.000565099946836 ko04720 Long-term potentiation 22/762 99/7206 0.000713308365129 ko04916 Melanogenesis 28/762 142/7206 0.00126042448223 ko05164 Influenza A 6/762 167/7206 0.00132535329815 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 18/762 79/7206 0.0013554422339 ko04972 Pancreatic secretion 23/762 111/7206 0.00149569982388 ko04976 Bile secretion 18/762 80/7206 0.00154258822241 ko04964 Proximal tubule bicarbonate reclamation 9/762 29/7206 0.00224088271094 ko04151 PI3K-Akt signaling pathway 60/762 390/7206 0.0022634617174 ko04110 Cell cycle 5/762 145/7206 0.00244438522619 ko04360 Axon guidance 39/762 233/7206 0.00327466874345 ko04925 Aldosterone synthesis and secretion 21/762 105/7206 0.0035200790688 ko04961 Endocrine and other factor-regulated calcium reabsorption 14/762 59/7206 0.00409745006406 ko04371 Apelin signaling pathway 31/762 177/7206 0.0041756115079 ko04540 Gap junction 24/762 128/7206 0.00520310820308 ko00350 Tyrosine metabolism 9/762 33/7206 0.00586837917129 ko04217 Necroptosis 8/762 178/7206 0.00610713327834 ko05162 Measles 4/762 120/7206 0.0063477952078 ko04630 Jak-STAT signaling pathway 5/762 132/7206 0.00639864096458 ko05016 Huntington's disease 11/762 215/7206 0.00650481383561 ko05161 Hepatitis B 8/762 173/7206 0.00802805810667 ko04711 Circadian rhythm - fly 5/762 13/7206 0.00813642165514 ko04621 NOD-like receptor signaling pathway 7/762 157/7206 0.00832483102209 ko04141 Protein processing in endoplasmic reticulum 9/762 184/7206 0.0101005958523 ko04744 Phototransduction 9/762 36/7206 0.0107434717094 ko05169 Epstein-Barr virus infection 11/762 206/7206 0.0109914930859 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/762 14/7206 0.0115728792111 ko04330 Notch signaling pathway 1/762 62/7206 0.0124575781561 ko05410 Hypertrophic cardiomyopathy (HCM) 19/762 100/7206 0.0125252261465 ko04612 Antigen processing and presentation 2/762 77/7206 0.0149681251762 ko04745 Phototransduction - fly 9/762 38/7206 0.0153675551325 ko05414 Dilated cardiomyopathy 20/762 112/7206 0.0187475474482 ko04260 Cardiac muscle contraction 18/762 98/7206 0.0189598802974 ko04010 MAPK signaling pathway 47/762 321/7206 0.0198701044747 ko05140 Leishmaniasis 2/762 75/7206 0.0216224500541 ko04146 Peroxisome 3/762 89/7206 0.0227355575282 ko04740 Olfactory transduction 15/762 80/7206 0.0260376337425 ko04620 Toll-like receptor signaling pathway 4/762 100/7206 0.0314684581026 ko04510 Focal adhesion 36/762 240/7206 0.0318895784806 ko05133 Pertussis 3/762 87/7206 0.0327269872073 ko04614 Renin-angiotensin system 5/762 18/7206 0.0347255325098 ko05110 Vibrio cholerae infection 12/762 63/7206 0.0375880409174 ko00830 Retinol metabolism 9/762 42/7206 0.0377614212131 ko04973 Carbohydrate digestion and absorption 9/762 42/7206 0.0377614212131 ko00590 Arachidonic acid metabolism 1/762 52/7206 0.0391913308089 ko00240 Pyrimidine metabolism 5/762 110/7206 0.0404797657001 ko00280 Valine, leucine and isoleucine degradation 1/762 54/7206 0.0410483769041 ko04710 Circadian rhythm 9/762 43/7206 0.0411279656307 ko04072 Phospholipase D signaling pathway 30/762 197/7206 0.0445922218731 ko04015 Rap1 signaling pathway 40/762 278/7206 0.0458105609335 ko04210 Apoptosis 11/762 180/7206 0.049022857596 ko04932 Non-alcoholic fatty liver disease (NAFLD) 11/762 182/7206 0.049530194351