ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	195/1133	423/7206	5.62082014617e-53
ko04724	Glutamatergic synapse	83/1133	152/7206	5.40194038503e-29
ko05033	Nicotine addiction	44/1133	56/7206	1.75872975469e-25
ko05032	Morphine addiction	63/1133	110/7206	9.2103136889e-24
ko04713	Circadian entrainment	70/1133	136/7206	1.37564892223e-22
ko04727	GABAergic synapse	59/1133	110/7206	2.23965310614e-20
ko04728	Dopaminergic synapse	80/1133	185/7206	1.45194767225e-19
ko04721	Synaptic vesicle cycle	48/1133	80/7206	1.47198822416e-19
ko04020	Calcium signaling pathway	98/1133	265/7206	6.64693411883e-18
ko04725	Cholinergic synapse	70/1133	160/7206	1.3917862123e-17
ko04024	cAMP signaling pathway	100/1133	279/7206	5.32649526865e-17
ko04723	Retrograde endocannabinoid signaling	70/1133	175/7206	4.1121540768e-15
ko04921	Oxytocin signaling pathway	77/1133	209/7206	4.04011619578e-14
ko04911	Insulin secretion	52/1133	117/7206	1.04618674359e-13
ko04726	Serotonergic synapse	57/1133	137/7206	2.16232190685e-13
ko04742	Taste transduction	34/1133	61/7206	6.42489096756e-13
ko04970	Salivary secretion	42/1133	95/7206	3.14923000118e-11
ko04261	Adrenergic signaling in cardiomyocytes	69/1133	205/7206	1.30730200418e-10
ko03040	Spliceosome	1/1133	145/7206	5.26220932809e-10
ko05203	Viral carcinogenesis	11/1133	277/7206	6.26294429948e-10
ko04744	Phototransduction	22/1133	36/7206	7.18019212567e-10
ko05031	Amphetamine addiction	38/1133	91/7206	2.04315244215e-09
ko04720	Long-term potentiation	38/1133	99/7206	3.27616516881e-08
ko05322	Systemic lupus erythematosus	3/1133	151/7206	4.40266342831e-08
ko04971	Gastric acid secretion	37/1133	98/7206	1.28695731491e-07
ko04022	cGMP-PKG signaling pathway	64/1133	216/7206	1.79136595399e-07
ko05168	Herpes simplex infection	7/1133	182/7206	4.66236260692e-07
ko04060	Cytokine-cytokine receptor interaction	8/1133	191/7206	5.52207521621e-07
ko04360	Axon guidance	66/1133	233/7206	8.50011172102e-07
ko04966	Collecting duct acid secretion	15/1133	26/7206	1.12634518773e-06
ko04120	Ubiquitin mediated proteolysis	4/1133	138/7206	1.49146497919e-06
ko04925	Aldosterone synthesis and secretion	36/1133	105/7206	2.16675229295e-06
ko04740	Olfactory transduction	30/1133	80/7206	2.68234563038e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1133	74/7206	2.94451107551e-06
ko03013	RNA transport	7/1133	166/7206	4.13618378391e-06
ko05164	Influenza A	7/1133	167/7206	4.22566956524e-06
ko04010	MAPK signaling pathway	81/1133	321/7206	6.58376301355e-06
ko04514	Cell adhesion molecules (CAMs)	41/1133	130/7206	7.39155914365e-06
ko04621	NOD-like receptor signaling pathway	7/1133	157/7206	1.20862201234e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1133	79/7206	1.39616587132e-05
ko04070	Phosphatidylinositol signaling system	36/1133	112/7206	1.74603392066e-05
ko05030	Cocaine addiction	26/1133	73/7206	2.68870991397e-05
ko04972	Pancreatic secretion	35/1133	111/7206	2.98727606643e-05
ko04924	Renin secretion	29/1133	86/7206	3.3031475601e-05
ko05169	Epstein-Barr virus infection	13/1133	206/7206	5.66542599212e-05
ko04260	Cardiac muscle contraction	31/1133	98/7206	6.70609782537e-05
ko04110	Cell cycle	7/1133	145/7206	6.98729190004e-05
ko04141	Protein processing in endoplasmic reticulum	11/1133	184/7206	7.96487521899e-05
ko04745	Phototransduction - fly	16/1133	38/7206	8.94729546349e-05
ko04730	Long-term depression	26/1133	78/7206	0.000109041779538
ko04976	Bile secretion	26/1133	80/7206	0.000154655767234
ko05110	Vibrio cholerae infection	22/1133	63/7206	0.000156866120968
ko05414	Dilated cardiomyopathy	33/1133	112/7206	0.000200474158545
ko05205	Proteoglycans in cancer	22/1133	271/7206	0.000232463998757
ko03008	Ribosome biogenesis in eukaryotes	2/1133	79/7206	0.000266002765665
ko05161	Hepatitis B	11/1133	173/7206	0.00027917130099
ko04540	Gap junction	36/1133	128/7206	0.000315524035916
ko04612	Antigen processing and presentation	2/1133	77/7206	0.000398887023279
ko05162	Measles	6/1133	120/7206	0.000526010039855
ko04750	Inflammatory mediator regulation of TRP channels	34/1133	122/7206	0.000592026871489
ko04064	NF-kappa B signaling pathway	4/1133	96/7206	0.000600600793057
ko05140	Leishmaniasis	2/1133	75/7206	0.000604736608091
ko04964	Proximal tubule bicarbonate reclamation	12/1133	29/7206	0.000822996233984
ko05166	HTLV-I infection	27/1133	292/7206	0.00131225383336
ko04014	Ras signaling pathway	64/1133	279/7206	0.00135441521858
ko04610	Complement and coagulation cascades	3/1133	79/7206	0.00157142211462
ko04072	Phospholipase D signaling pathway	47/1133	197/7206	0.0027238057273
ko04978	Mineral absorption	14/1133	40/7206	0.00320435797804
ko00590	Arachidonic acid metabolism	1/1133	52/7206	0.00321174938422
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1133	100/7206	0.00338107842353
ko04626	Plant-pathogen interaction	8/1133	18/7206	0.0036399492133
ko04923	Regulation of lipolysis in adipocytes	22/1133	77/7206	0.00400347184581
ko04330	Notch signaling pathway	2/1133	62/7206	0.00419126023308
ko05219	Bladder cancer	1/1133	48/7206	0.00456557321157
ko04371	Apelin signaling pathway	42/1133	177/7206	0.00460172417026
ko04922	Glucagon signaling pathway	32/1133	128/7206	0.00653417633782
ko00071	Fatty acid degradation	1/1133	45/7206	0.00681761530723
ko03420	Nucleotide excision repair	1/1133	46/7206	0.0069444192702
ko04657	IL-17 signaling pathway	5/1133	87/7206	0.00713934202363
ko00562	Inositol phosphate metabolism	24/1133	89/7206	0.00751558407483
ko04630	Jak-STAT signaling pathway	10/1133	132/7206	0.00754293336898
ko00480	Glutathione metabolism	2/1133	55/7206	0.00853146048097
ko05321	Inflammatory bowel disease (IBD)	2/1133	56/7206	0.00867849161079
ko04915	Estrogen signaling pathway	32/1133	131/7206	0.0103206888965
ko03022	Basal transcription factors	1/1133	44/7206	0.0106698873454
ko05206	MicroRNAs in cancer	16/1133	177/7206	0.0117837090809
ko05215	Prostate cancer	8/1133	111/7206	0.0118033203129
ko00280	Valine, leucine and isoleucine degradation	2/1133	54/7206	0.0129283581484
ko05145	Toxoplasmosis	10/1133	126/7206	0.0131151214992
ko05016	Huntington's disease	21/1133	215/7206	0.0131878351285
ko04622	RIG-I-like receptor signaling pathway	3/1133	62/7206	0.0134784774868
ko04214	Apoptosis - fly	4/1133	72/7206	0.0138317565861
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1133	14/7206	0.0143746358073
ko04146	Peroxisome	6/1133	89/7206	0.0180215631569
ko04217	Necroptosis	17/1133	178/7206	0.0213550432944
ko05133	Pertussis	6/1133	87/7206	0.0247876788423
ko05217	Basal cell carcinoma	4/1133	68/7206	0.0275910630309
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1133	182/7206	0.0297301315964
ko05131	Shigellosis	6/1133	82/7206	0.0324506335765
ko03018	RNA degradation	6/1133	84/7206	0.0331695025299
ko00860	Porphyrin and chlorophyll metabolism	1/1133	34/7206	0.0337556117396
ko00310	Lysine degradation	5/1133	73/7206	0.0348780833448
ko04710	Circadian rhythm	12/1133	43/7206	0.0351674244657
ko04115	p53 signaling pathway	5/1133	74/7206	0.0352866472904
ko04640	Hematopoietic cell lineage	4/1133	64/7206	0.037020314258
ko04510	Focal adhesion	26/1133	240/7206	0.0375133356483
ko05144	Malaria	2/1133	45/7206	0.0377067772282
ko04140	Autophagy - animal	16/1133	164/7206	0.0383669023474
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1133	92/7206	0.0419432832973
ko04113	Meiosis - yeast	5/1133	70/7206	0.0472279239453
ko04658	Th1 and Th2 cell differentiation	8/1133	96/7206	0.0472866080709
ko04961	Endocrine and other factor-regulated calcium reabsorption	15/1133	59/7206	0.0475634477966