ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 64/820 152/7206 1.36729195892e-22 ko05033 Nicotine addiction 36/820 56/7206 4.33995792027e-21 ko04721 Synaptic vesicle cycle 41/820 80/7206 1.0633889868e-18 ko04080 Neuroactive ligand-receptor interaction 111/820 423/7206 1.83631930373e-18 ko04727 GABAergic synapse 45/820 110/7206 1.23298836555e-15 ko04728 Dopaminergic synapse 61/820 185/7206 1.93867808149e-15 ko05032 Morphine addiction 44/820 110/7206 6.90373586271e-15 ko04713 Circadian entrainment 48/820 136/7206 1.17694754186e-13 ko04723 Retrograde endocannabinoid signaling 53/820 175/7206 6.48583475184e-12 ko04725 Cholinergic synapse 48/820 160/7206 9.57221053224e-11 ko04911 Insulin secretion 38/820 117/7206 7.29234217407e-10 ko04024 cAMP signaling pathway 67/820 279/7206 1.11931430284e-09 ko04742 Taste transduction 23/820 61/7206 7.82659800028e-08 ko04744 Phototransduction 17/820 36/7206 8.06230318266e-08 ko05031 Amphetamine addiction 28/820 91/7206 4.60069824297e-07 ko04360 Axon guidance 53/820 233/7206 4.99520428808e-07 ko04514 Cell adhesion molecules (CAMs) 35/820 130/7206 7.84026266601e-07 ko05030 Cocaine addiction 24/820 73/7206 7.9593934697e-07 ko03040 Spliceosome 1/820 145/7206 8.69506389473e-07 ko04726 Serotonergic synapse 36/820 137/7206 9.14858770264e-07 ko05203 Viral carcinogenesis 9/820 277/7206 1.01463004916e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 24/820 74/7206 1.0533194643e-06 ko04261 Adrenergic signaling in cardiomyocytes 45/820 205/7206 1.00146317955e-05 ko04060 Cytokine-cytokine receptor interaction 5/820 191/7206 1.35556835954e-05 ko04720 Long-term potentiation 27/820 99/7206 1.54107333795e-05 ko05168 Herpes simplex infection 5/820 182/7206 2.7275383553e-05 ko04120 Ubiquitin mediated proteolysis 3/820 138/7206 0.000110349892546 ko05164 Influenza A 5/820 167/7206 0.000111708136767 ko04621 NOD-like receptor signaling pathway 5/820 157/7206 0.000314868845512 ko04966 Collecting duct acid secretion 10/820 26/7206 0.000331466164036 ko00604 Glycosphingolipid biosynthesis - ganglio series 7/820 14/7206 0.000401669225108 ko03013 RNA transport 6/820 166/7206 0.00047771519178 ko04010 MAPK signaling pathway 57/820 321/7206 0.000577647694928 ko05162 Measles 3/820 120/7206 0.000687175578862 ko04970 Salivary secretion 22/820 95/7206 0.000919536079176 ko05322 Systemic lupus erythematosus 6/820 151/7206 0.00175559128785 ko05205 Proteoglycans in cancer 16/820 271/7206 0.00241293961946 ko04214 Apoptosis - fly 1/820 72/7206 0.0025522674097 ko04961 Endocrine and other factor-regulated calcium reabsorption 15/820 59/7206 0.0027509164694 ko04540 Gap junction 26/820 128/7206 0.00285769757184 ko04141 Protein processing in endoplasmic reticulum 9/820 184/7206 0.00307554869825 ko04730 Long-term depression 18/820 78/7206 0.00325323035265 ko04260 Cardiac muscle contraction 21/820 98/7206 0.00350934352155 ko04146 Peroxisome 2/820 89/7206 0.00356189416606 ko05169 Epstein-Barr virus infection 11/820 206/7206 0.00362797990476 ko04391 Hippo signaling pathway - fly 20/820 90/7206 0.00371194012332 ko04972 Pancreatic secretion 23/820 111/7206 0.00376862220334 ko01200 Carbon metabolism 5/820 128/7206 0.00453192100957 ko03018 RNA degradation 2/820 84/7206 0.0049607555969 ko04921 Oxytocin signaling pathway 37/820 209/7206 0.00549215350394 ko04064 NF-kappa B signaling pathway 3/820 96/7206 0.00564914318229 ko00564 Glycerophospholipid metabolism 3/820 99/7206 0.00587365107882 ko00240 Pyrimidine metabolism 4/820 110/7206 0.00604964006197 ko03008 Ribosome biogenesis in eukaryotes 2/820 79/7206 0.00707534584604 ko05140 Leishmaniasis 2/820 75/7206 0.0101780509039 ko04976 Bile secretion 17/820 80/7206 0.0114781813624 ko04022 cGMP-PKG signaling pathway 37/820 216/7206 0.0117748002528 ko04140 Autophagy - animal 9/820 164/7206 0.0126105561498 ko00330 Arginine and proline metabolism 1/820 61/7206 0.0128200977921 ko04950 Maturity onset diabetes of the young 8/820 29/7206 0.0131648615766 ko00310 Lysine degradation 2/820 73/7206 0.0146799053472 ko04014 Ras signaling pathway 45/820 279/7206 0.015738755843 ko05146 Amoebiasis 4/820 99/7206 0.0161085864793 ko04915 Estrogen signaling pathway 24/820 131/7206 0.0173280128939 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 16/820 79/7206 0.0191865082118 ko04512 ECM-receptor interaction 16/820 79/7206 0.0191865082118 ko04962 Vasopressin-regulated water reabsorption 13/820 58/7206 0.0193004653064 ko04138 Autophagy - yeast 3/820 81/7206 0.0220598453847 ko04137 Mitophagy - animal 3/820 82/7206 0.0220614294363 ko04971 Gastric acid secretion 19/820 98/7206 0.0231095951108 ko05110 Vibrio cholerae infection 13/820 63/7206 0.0274413002251 ko00280 Valine, leucine and isoleucine degradation 1/820 54/7206 0.0277446190216 ko04640 Hematopoietic cell lineage 2/820 64/7206 0.0296508934488 ko04611 Platelet activation 10/820 163/7206 0.0330777954229 ko04020 Calcium signaling pathway 41/820 265/7206 0.038070466413 ko00270 Cysteine and methionine metabolism 1/820 47/7206 0.0381424110461 ko05204 Chemical carcinogenesis 1/820 48/7206 0.0382287820662 ko05418 Fluid shear stress and atherosclerosis 11/820 173/7206 0.0382943026514 ko05161 Hepatitis B 11/820 173/7206 0.0382943026514 ko00512 Mucin type O-glycan biosynthesis 7/820 29/7206 0.0400531766478 ko04964 Proximal tubule bicarbonate reclamation 7/820 29/7206 0.0400531766478 ko04924 Renin secretion 16/820 86/7206 0.0401240865088 ko04657 IL-17 signaling pathway 4/820 87/7206 0.0413736247768 ko00010 Glycolysis / Gluconeogenesis 3/820 74/7206 0.0425963250834 ko04145 Phagosome 27/820 162/7206 0.0439035248381 ko04612 Antigen processing and presentation 3/820 77/7206 0.0442188115584 ko04110 Cell cycle 9/820 145/7206 0.0470878688063 ko05034 Alcoholism 37/820 238/7206 0.0478271977181 ko04740 Olfactory transduction 15/820 80/7206 0.0490454430667