ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 88/794 145/7206 1.69259756666e-48 ko03013 RNA transport 84/794 166/7206 6.5503219624e-38 ko03008 Ribosome biogenesis in eukaryotes 49/794 79/7206 6.5848192017e-28 ko05322 Systemic lupus erythematosus 66/794 151/7206 3.36271931802e-25 ko03440 Homologous recombination 31/794 41/7206 4.50557935559e-22 ko04080 Neuroactive ligand-receptor interaction 1/794 423/7206 7.24340535738e-21 ko04110 Cell cycle 59/794 145/7206 1.0190440112e-20 ko03030 DNA replication 28/794 38/7206 1.56871699269e-19 ko04111 Cell cycle - yeast 42/794 90/7206 1.03139178846e-17 ko03460 Fanconi anemia pathway 29/794 51/7206 1.49886500339e-15 ko05034 Alcoholism 70/794 238/7206 2.1775101786e-15 ko04113 Meiosis - yeast 31/794 70/7206 1.22529835492e-12 ko00240 Pyrimidine metabolism 40/794 110/7206 1.61961091277e-12 ko03020 RNA polymerase 19/794 29/7206 3.54091652188e-12 ko03015 mRNA surveillance pathway 35/794 93/7206 1.31745947775e-11 ko03430 Mismatch repair 16/794 22/7206 1.6155600454e-11 ko04020 Calcium signaling pathway 2/794 265/7206 1.96194482079e-11 ko03420 Nucleotide excision repair 23/794 46/7206 4.75095162935e-11 ko04144 Endocytosis 7/794 342/7206 2.39670528735e-10 ko05203 Viral carcinogenesis 64/794 277/7206 3.81219156589e-09 ko03018 RNA degradation 28/794 84/7206 3.42652044078e-08 ko04723 Retrograde endocannabinoid signaling 1/794 175/7206 5.1688025717e-08 ko04024 cAMP signaling pathway 7/794 279/7206 1.36718162784e-07 ko05010 Alzheimer's disease 3/794 202/7206 2.64429503006e-07 ko03410 Base excision repair 16/794 38/7206 8.69902409664e-07 ko05169 Epstein-Barr virus infection 45/794 206/7206 4.60251744986e-06 ko04514 Cell adhesion molecules (CAMs) 1/794 130/7206 6.60482706983e-06 ko04015 Rap1 signaling pathway 10/794 278/7206 8.54005091466e-06 ko00970 Aminoacyl-tRNA biosynthesis 16/794 44/7206 8.60294894072e-06 ko03050 Proteasome 18/794 54/7206 9.77064469923e-06 ko00190 Oxidative phosphorylation 1/794 127/7206 9.9977627063e-06 ko04932 Non-alcoholic fatty liver disease (NAFLD) 4/794 182/7206 1.10188707704e-05 ko04022 cGMP-PKG signaling pathway 6/794 216/7206 1.18928414368e-05 ko04725 Cholinergic synapse 3/794 160/7206 1.73016640854e-05 ko04151 PI3K-Akt signaling pathway 19/794 390/7206 1.89389305848e-05 ko04921 Oxytocin signaling pathway 6/794 209/7206 2.43280347652e-05 ko04810 Regulation of actin cytoskeleton 10/794 264/7206 3.19642463219e-05 ko04261 Adrenergic signaling in cardiomyocytes 6/794 205/7206 3.41502209471e-05 ko04911 Insulin secretion 1/794 117/7206 3.43603540199e-05 ko05200 Pathways in cancer 28/794 492/7206 3.64747985093e-05 ko03022 Basal transcription factors 15/794 44/7206 3.9859243225e-05 ko05152 Tuberculosis 5/794 187/7206 4.1764141325e-05 ko04120 Ubiquitin mediated proteolysis 32/794 138/7206 4.33827179447e-05 ko04114 Oocyte meiosis 32/794 139/7206 4.67205258776e-05 ko04062 Chemokine signaling pathway 6/794 201/7206 4.7889893135e-05 ko05414 Dilated cardiomyopathy 1/794 112/7206 4.95311011083e-05 ko04510 Focal adhesion 9/794 240/7206 5.73328361776e-05 ko04371 Apelin signaling pathway 5/794 177/7206 8.07441125673e-05 ko04218 Cellular senescence 37/794 177/7206 0.000125390996265 ko05012 Parkinson's disease 4/794 155/7206 0.000138753097001 ko04621 NOD-like receptor signaling pathway 4/794 157/7206 0.000141903826183 ko04530 Tight junction 9/794 228/7206 0.000149519836029 ko04726 Serotonergic synapse 3/794 137/7206 0.000160740706895 ko05410 Hypertrophic cardiomyopathy (HCM) 1/794 100/7206 0.000163823642834 ko04010 MAPK signaling pathway 16/794 321/7206 0.000165023820319 ko04728 Dopaminergic synapse 6/794 185/7206 0.000182977350594 ko04142 Lysosome 4/794 151/7206 0.000198092061998 ko04270 Vascular smooth muscle contraction 4/794 154/7206 0.00020671094733 ko04611 Platelet activation 5/794 163/7206 0.000325114559654 ko04360 Axon guidance 10/794 233/7206 0.000387776041476 ko00230 Purine metabolism 38/794 194/7206 0.000407679760145 ko03060 Protein export 9/794 23/7206 0.000446850876007 ko05145 Toxoplasmosis 3/794 126/7206 0.000479942172231 ko01200 Carbon metabolism 3/794 128/7206 0.000493770794778 ko04146 Peroxisome 1/794 89/7206 0.000539033676643 ko04014 Ras signaling pathway 14/794 279/7206 0.000579118674701 ko04750 Inflammatory mediator regulation of TRP channels 3/794 122/7206 0.000688562980939 ko04659 Th17 cell differentiation 2/794 106/7206 0.000804222155084 ko04670 Leukocyte transendothelial migration 5/794 151/7206 0.000890024263784 ko05142 Chagas disease (American trypanosomiasis) 4/794 130/7206 0.00161661684883 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 1/794 79/7206 0.00175610744853 ko04721 Synaptic vesicle cycle 1/794 80/7206 0.00178474810341 ko04976 Bile secretion 1/794 80/7206 0.00178474810341 ko05418 Fluid shear stress and atherosclerosis 7/794 173/7206 0.0018709762426 ko04972 Pancreatic secretion 3/794 111/7206 0.00200795848021 ko04914 Progesterone-mediated oocyte maturation 22/794 104/7206 0.0023053179555 ko04658 Th1 and Th2 cell differentiation 2/794 96/7206 0.00254441869721 ko04933 AGE-RAGE signaling pathway in diabetic complications 5/794 135/7206 0.00331116685971 ko04920 Adipocytokine signaling pathway 2/794 89/7206 0.00346158670384 ko03450 Non-homologous end-joining 6/794 15/7206 0.00365826318929 ko04925 Aldosterone synthesis and secretion 3/794 105/7206 0.00411709537402 ko04915 Estrogen signaling pathway 5/794 131/7206 0.00456943285159 ko04668 TNF signaling pathway 4/794 120/7206 0.00457719193116 ko04630 Jak-STAT signaling pathway 5/794 132/7206 0.00459334564122 ko04380 Osteoclast differentiation 5/794 134/7206 0.00475866993847 ko01230 Biosynthesis of amino acids 2/794 85/7206 0.00499656227536 ko05133 Pertussis 2/794 87/7206 0.00506274587129 ko00564 Glycerophospholipid metabolism 3/794 99/7206 0.0057372936274 ko04916 Melanogenesis 6/794 142/7206 0.00629532460906 ko05132 Salmonella infection 3/794 98/7206 0.00831158802257 ko04640 Hematopoietic cell lineage 1/794 64/7206 0.00832325355684 ko05205 Proteoglycans in cancer 17/794 271/7206 0.00977639056104 ko04512 ECM-receptor interaction 2/794 79/7206 0.0103670138689 ko04072 Phospholipase D signaling pathway 11/794 197/7206 0.0108073237283 ko05168 Herpes simplex infection 31/794 182/7206 0.0116706070092 ko04912 GnRH signaling pathway 5/794 122/7206 0.0121246016855 ko04666 Fc gamma R-mediated phagocytosis 5/794 122/7206 0.0121246016855 ko01212 Fatty acid metabolism 1/794 60/7206 0.0122359664622 ko00600 Sphingolipid metabolism 1/794 63/7206 0.0129951019339 ko05140 Leishmaniasis 2/794 75/7206 0.0147985838738 ko04923 Regulation of lipolysis in adipocytes 2/794 77/7206 0.0154072617987 ko03010 Ribosome 6/794 129/7206 0.0154617272682 ko05323 Rheumatoid arthritis 3/794 89/7206 0.016019186701 ko04520 Adherens junction 4/794 103/7206 0.0163903649564 ko05031 Amphetamine addiction 3/794 91/7206 0.0166141832811 ko05166 HTLV-I infection 45/794 292/7206 0.0170694409264 ko04390 Hippo signaling pathway 11/794 188/7206 0.0181166105257 ko05167 Kaposi's sarcoma-associated herpesvirus infection 11/794 191/7206 0.0183826411147 ko04540 Gap junction 6/794 128/7206 0.0213389144336 ko04071 Sphingolipid signaling pathway 9/794 162/7206 0.0218630856414 ko04145 Phagosome 9/794 162/7206 0.0218630856414 ko04918 Thyroid hormone synthesis 3/794 86/7206 0.0226137949075 ko04620 Toll-like receptor signaling pathway 4/794 100/7206 0.0227831379261 ko05202 Transcriptional misregulation in cancer 31/794 188/7206 0.0239650827018 ko04931 Insulin resistance 7/794 137/7206 0.0262514289271 ko04930 Type II diabetes mellitus 1/794 54/7206 0.0266482800271 ko00280 Valine, leucine and isoleucine degradation 1/794 54/7206 0.0266482800271 ko00520 Amino sugar and nucleotide sugar metabolism 1/794 55/7206 0.0273030835854 ko05164 Influenza A 10/794 167/7206 0.0332183601264 ko04623 Cytosolic DNA-sensing pathway 9/794 41/7206 0.0396885919061 ko05120 Epithelial cell signaling in Helicobacter pylori infection 4/794 92/7206 0.0423111448028 ko00561 Glycerolipid metabolism 2/794 63/7206 0.0424268505478 ko05130 Pathogenic Escherichia coli infection 3/794 77/7206 0.0430394218396 ko04612 Antigen processing and presentation 3/794 77/7206 0.0430394218396 ko04922 Glucagon signaling pathway 7/794 128/7206 0.044932361842