Method of omim prediction
We use the RWRH (random walk with restart on heterogeneous network) algorithm1 to analyze the relationship between lncRNA and OMIM in MATLAB. The upper subnetwork is coding-lncRNA gene co-expression network, and the lower network is OMIM similarity network. OMIM similarity matrix is from Disimweb2 and gene-OMIM relationship is from InterMine3.
1. Li, Y. & Patra, J. C. Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network. Bioinformatics 26, 1219-1224, doi:10.1093/bioinformatics/btq108 (2010).
2. Caniza, H., Romero, A. E. & Paccanaro, A. A network medicine approach to quantify distance between hereditary disease modules on the interactome. Sci Rep 5, 17658, doi:10.1038/srep17658 (2015).
3. Smith, R. N. et al. InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics 28, 3163-3165, doi:10.1093/bioinformatics/bts577 (2012).
| ZFLNC lncRNA | OMIM | Phenotype |
|---|---|---|
| ZFLNCG10480 | 605432 | Radioulnar synostosis with amegakaryocytic thrombocytopenia 1 |
| ZFLNCG01205 | 614880 | Hypogonadotropic hypogonadism 15 with or without anosmia |
| ZFLNCG13205 | 601419 | Myopathy, myofibrillar, 1 |
| ZFLNCG12013 | 265120 | Surfactant metabolism dysfunction, pulmonary, 1 |
| ZFLNCG01355 | 613838 | Cardiomyopathy, hypertrophic, 16 |
| ZFLNCG00532 | 237500 | Dubin-Johnson syndrome |
| ZFLNCG09907 | 133200 | Erythrokeratodermia variabilis et progressiva |
| ZFLNCG06494 | 234200 | Neurodegeneration with brain iron accumulation 1 |
| ZFLNCG04393 | 116920 | Leukocyte adhesion deficiency |
| ZFLNCG12109 | 227810 | Fanconi-Bickel syndrome |
| ZFLNCG06198 | 142945 | Holoprosencephaly-3 |
| ZFLNCG07711 | 612634 | Microvascular complications of diabetes 6 |
| ZFLNCG01621 | 261600 | Phenylketonuria |
| ZFLNCG03687 | 609532 | Hepatitic C virus, susceptibility to |
| ZFLNCG04372 | 611038 | Microphthalmia, isolated 3 |
| ZFLNCG12274 | 613980 | Atrial fibrillation, familial, 9 |
| ZFLNCG08256 | 615159 | Mitochondrial complex III deficiency, nuclear type 4 |
| ZFLNCG02067 | 611377 | Brachydactyly, type B2 |
| ZFLNCG01488 | 173200 | Pityriasis rubra pilaris |
| ZFLNCG05355 | 261740 | Glycogen storage disease of heart, lethal congenital |
| ZFLNCG03375 | 602522 | Sensorineural deafness with mild renal dysfunction |
| ZFLNCG00470 | 612714 | Exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis |
| ZFLNCG11824 | 278250 | Wrinkly skin syndrome |
| ZFLNCG01312 | 278250 | Wrinkly skin syndrome |
| ZFLNCG05576 | 614483 | Porencephaly 2 |