Method of omim prediction
We use the RWRH (random walk with restart on heterogeneous network) algorithm1 to analyze the relationship between lncRNA and OMIM in MATLAB. The upper subnetwork is coding-lncRNA gene co-expression network, and the lower network is OMIM similarity network. OMIM similarity matrix is from Disimweb2 and gene-OMIM relationship is from InterMine3.
1. Li, Y. & Patra, J. C. Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network. Bioinformatics 26, 1219-1224, doi:10.1093/bioinformatics/btq108 (2010).
2. Caniza, H., Romero, A. E. & Paccanaro, A. A network medicine approach to quantify distance between hereditary disease modules on the interactome. Sci Rep 5, 17658, doi:10.1038/srep17658 (2015).
3. Smith, R. N. et al. InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics 28, 3163-3165, doi:10.1093/bioinformatics/bts577 (2012).
| ZFLNC lncRNA | OMIM | Phenotype |
|---|---|---|
| ZFLNCG12894 | 614437 | Cutis laxa, autosomal recessive, type IB |
| ZFLNCG10914 | 268150 | Anemia, hemolytic, Rh-null, regulator type |
| ZFLNCG04502 | 254130 | Miyoshi muscular dystrophy 1 |
| ZFLNCG07994 | 602078 | Fibrosis of extraocular muscles, congenital, 2 |
| ZFLNCG08398 | 180105 | Retinitis pigmentosa 10 |
| ZFLNCG00362 | 233910 | Hyperphenylalaninemia, BH4-deficient, B |
| ZFLNCG03474 | 169100 | Char syndrome |
| ZFLNCG05895 | 607507 | Psoriatic arthritis, susceptibility to |
| ZFLNCG12995 | 613980 | Atrial fibrillation, familial, 9 |
| ZFLNCG12564 | 601042 | Dystonia 9 |
| ZFLNCG05682 | 214800 | CHARGE syndrome |
| ZFLNCG08297 | 122000 | Corneal dystrophy, posterior polymorphous, 1 |
| ZFLNCG13205 | 604765 | Cardiomyopathy, dilated, 1I |
| ZFLNCG06108 | 615182 | Combined D-2- and L-2-hydroxyglutaric aciduria |
| ZFLNCG09539 | 276880 | Urocanase deficiency |
| ZFLNCG05975 | 178600 | Pulmonary hypertension, primary, fenfluramine or dexfenfluramine-associated |
| ZFLNCG08559 | 614063 | N-acetylaspartate deficiency |
| ZFLNCG04946 | 610743 | Spinocerebellar ataxia, autosomal recessive 8 |
| ZFLNCG08626 | 604765 | Cardiomyopathy, dilated, 1I |
| ZFLNCG05735 | 613353 | Mononeuropathy of the median nerve, mild |
| ZFLNCG07294 | 206900 | Optic nerve hypoplasia and abnormalities of the central nervous system |
| ZFLNCG05895 | 609464 | Sarcoidosis, early-onset |
| ZFLNCG09301 | 155240 | Medullary thyroid carcinoma |
| ZFLNCG05577 | 614519 | Hemorrhage, intracerebral, susceptibility to |
| ZFLNCG09633 | 614131 | Glomerulosclerosis, focal segmental, 6 |